Genomics Clinical Academic Group
The Genomics Clinical Academic Group aims to establish City St George's, University of London and St George's Hospital as a world leader in genomic medicine.
Our Mission
Our mission is to foster collaborations between science and healthcare to:
- deliver better healthcare for patients
- conduct cutting edge research
- train the genomics workforce of the future.
What we do
Click the items below to learn more about what the Genomics Clinical Academic Group (G CAG) does.
Research
We hold cross-institutional mini-symposiums to raise awareness of the research already happening at City St George’s, which covers a wide range of topics with researchers from a range of different research sections in the City St George's Institutes.
The Genomics CAG has links with many departments at City St George's, particularly the Neuroscience and Cell Biology Research Institute and the Cardiovascular and Genomics Research Institute where researchers are studying various themes such as cardiovascular and neurosciences with many researchers linking to our genetics and genomics research groups.
Education and training
We have an excellent portfolio of education and training opportunities designed to address a range of topics and levels of experience.
The Genomic Medicine programme is a suite of modules designed to upskill and educate in the application of genomics across healthcare. It is possible to take individual modules for continuing professional development (CPD) purposes or complete a full academic award (PGCert, PGDip, MSc). Our flagship blended-learning programme is comprised of 13 modules:
- Fundamentals of human genetics and genomics
- Omics techniques and technologies
- Bioinformatics, quality assurance and data interpretation
- Advanced bioinformatics
- Genomics of common and rare inherited disease
- Application of genomics in infectious disease
- Molecular pathology of cancer and application in diagnosis, screening and treatment
- Pharmacogenomics and stratified healthcare
- Genomics of neurological disorders
- Genomics of cardiovascular disorders
- Ethical, legal and social issues in applied genomics
- Introduction to counselling skills in genomics
- Fetal genomics
Each module is delivered in a block of 5 days of primarily face-to-face learning either at the Tooting Campus of City St George's or at our partners King's College London. NHS staff may benefit from full-fee funding from NHS England.
New for 2025 is our fully online PgCert Genomic Medicine which is comprised of three core modules (Fundamentals of human genetics and genomics; Genomics of common and rare inherited disease; and Variant interpretation) alongside a fourth module chosen from either Genomics of neurological disorders or Genomics of cardiovascular disorders. Each module will run across a 10-week period with students able to complete learning when it suits them best. It is also possible to complete individual modules.
The G CAG has also been involved in developing a range of shorter courses most of which are fully online. We have a set of cutting-edge massive online open courses (MOOCs) available through the Future Learn platform, all of which can be accessed free of charge. These MOOCs are:
- The Genomics Era: the Future of Genetics in Medicine
- Genetic Inheritance for the Pregnancy Pathway: A Practical Guide for Clinicians
- Genomic Technologies in Clinical Diagnostics: Molecular Techniques
- Genomic Technologies in Clinical Diagnostics: Next Generation Sequencing
- Interpreting Genomic Variation: Inherited Cancer Susceptibility.
These can be completed across two to five weeks in your own time, being fully self-directed.
There are also two short courses led by expert members of the G-CAG and including highly interactive sessions. The first is aimed at Oncologists and the second at a more general audience of clinical and healthcare professionals:
- Practical Cancer Genomics for Oncologists
- Practical Genomics and Genetic Testing for the Non-Geneticist.
Watch this space as we look to develop more education and training for those involved and interested in genomics!
Clinical genomics
The Clinical Genetics service covers a population of 4 million in South West London, Surrey and West Sussex. A multidisciplinary team of doctors, genetic counsellors, specialist nurses and clinical scientists provide support to children and adults affected by or at risk of genetic disorders. The department is a lead training centre for specialist registrars, genetic counsellors, and clinical scientists.
Across St George’s Hospital several highly specialised disease specific genetic services have been established including:
- Tuberous Sclerosis Complex Clinic
- Primary Lymphoedema Service
- Huntington’s Disease MDT Clinic
- Inherited Cardiovascular Conditions Service
- Paroxysmal Movement Disorders
- Neurogenetics Nurse Led Service.
St George’s clinical teams are active members of seven Rare Disease Collaborative Networks. We work closely with the South East Genomic Medicine Service Alliance for which Dr Frances Elmslie is Clinical Director.
Events and news
Metagenomics in Action
Metagenomics is a rapidly expanding area as a diagnostic tool for infections. It bypasses the need to grow individual microbes in a lab by analysing the genetic material from all microbes in a human sample, including bacteria, viruses and fungi.
Metagenomics is already being used as a diagnostic tool for respiratory patients, as well as those with brain or central nervous system infections. What started as a pilot at Guy’s and St Thomas’ is now being rolled out to 30 sites across the NHS, including St George’s.
Join us on October 16th, for a unique opportunity to meet with world leading metagenomic experts including
- Professor Jonathan Edgeworth, Director at the Centre for Clinical Infection & Diagnostic Research, St Thomas’ Hospital
- Professor Judy Breuer, Professor of Virology, UCL & Clinical Lead for Virology, GOSH
- Anna Aryee, Consultant in Infectious Diseases & Microbiology at UK Health Security Agency and Barts Health NHS Trust.
Hear how they are already using this cutting edge technology in the NHS to benefit patients and the important role this will have for biosecurity.
This is event is open to everyone so do share with colleagues.
📅 Date: 16 October 2025
🕐 Time: 12:00 – 14:00
🔗 Register here: https://bit.ly/41yERm3
Genomics Clinical Academic Group seminar series
2025 dates
These meetings take place on Mondays from 12:00 to 13:00 in Lecture Theatre A, B or C and online.
| Date | Speaker | Institute | Speech title | Location | Join online |
|---|---|---|---|---|---|
| 15 September 2025 | Judith Breuer | UCL | Metagenomics in CNS infections | Lecture Theatre A | Join via MS Teams. |
| 29 September 2025 | Greg Findlay | The Crick Institute | Saturation genome editing to guide clinical interpretation of variants of uncertain significance. | Lecture Theatre A | Join via MS Teams. |
| 20 October 2025 | Prof Andreas Brunklaus | Royal Hospital for Children, Glasgow and School of Health & Medical Sciences | The next frontier in epilepsy genetics - advances in diagnostics, clinical phenotyping and therapeutics. | Lecture Theatre C | Join via MS Teams. |
| 17 November 2025 | Clare Turnbull | Institute of Cancer Research | Transitioning of cancer susceptibility genetics from the clinic to the population: Considerations and cautions. | Lecture Theatre C | Join via MS Teams. |
| 15 December 2025 | Diana Baralle | Genomics Medicine | RNA in Genomic Medicine. | Lecture Theatre A | Join via MS Teams. |
Who we are
The Genomics-CAG is led by a Director, Dr Emma Matthews, supported by an administrator and a 15-member Steering Committee that meets quarterly to set key priorities and monitor performance.
- Alan Pittman (Bioinformatician (also I&I), Senior Lecturer in Computational Genetics) - apittman@citystgeorges.ac.uk
- Bethan Frugtniet (Clinical Scientist, St George's Genomics Service) - bethan.frugtniet@stgeorges.nhs.uk
- Dan Osborn (Senior Lecturer) - dosborn@citystgeorges.ac.uk
- Emma Matthews (Genomics CAG Director, Academic Neurologist) - ematthew@citystgeorges.ac.uk
- Esther Dempsey (CRTF, Training Representative) - edempsey@citystgeorges.ac.uk
- Frances Elmslie (Genomics Board) - frances.elmslie@nhs.net
- Kate Everett (Reader, Genomics Postgraduate and Undergraduate Course Director) - keverett@citystgeorges.ac.uk
- Meriel McEntagart (NHS (Clinical Genetics) and GEL) - meriel.mcentagart@nhs.net
- Nayana Lahiri (NHS Clinical Genetics Care Group Lead) - nayana.lahiri@stgeorges.nhs.net / nlahiri@citystgeorges.ac.uk
- Nidhi Sofat (Training Programme (GAT)) - nsofat@citystgeorges.ac.uk
- Pia Ostergaard (Genomics Research Centre) - posterga@citystgeorges.ac.uk
- Sahar Mansour (Professor/NHS Consultant) - smansour@citystgeorges.ac.uk
- Christopher Carroll (Lecturer) - ccarroll@citystgeorges.ac.uk
- Silvia Almedina (Lecturer) - snartina@citystgeorges.ac.uk
- Luigi D'Argenzio (Consultant Paediatric Neurologist) - luigi.dargenzio@stgeorges.nhs.uk
CAG Symposiums
In partnership with St George’s University Hospitals NHS Foundation Trust, we have established four Clinical Academic Groups (CAGs) in cardiovascular diseases, neurosciences, infectious diseases and genomic medicine.
The CAGs host joint and individual symposiums on a regular basis as an opportunity to share research, hear about new clinical services in each area and encourage collaboration between the disciplines of each group.
Many of the past symposiums have been recorded and you can find details here.